BobbiSue’s Glucose

Course Objective:

“Describe how the kidneys reabsorb glucose and explain how glycosuria is produced.”

BobbiSue is a 4-year-old girl with a rare genetic defect that causes the Na+/glucose symporters in the proximal tubule to reabsorb less glucose and sodium ions than normal. Predict the effects this defect will have on the composition and volume of BobbiSue’s urine.

The Question for you to answer and discuss is:

    Explain why you would expect to see increased activity of the tubuloglomerular feedback and the renin-angiotensin-aldosterone systems in BobbiSue’s kidneys.